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Journal / Developmental Biology / Generation av standardiserade och reproducerbara…
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Developmental Biology

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JoVE Journal Developmental Biology
Generation av standardiserade och reproducerbara framhjärnan-typ Cerebral Organoids från mänskliga inducerade pluripotenta stamceller
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Generation av standardiserade och reproducerbara framhjärnan-typ Cerebral Organoids från mänskliga inducerade pluripotenta stamceller

Article DOI: 10.3791/56768-v • 10:25 min • January 23rd, 2018
January 23rd, 2018 •
*1, *1, 1, 1,2,3, 1
1Institute of Reconstructive Neurobiology, University of Bonn, 2Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim, 3Hector Institute for Translational Brain Research (HITBR gGmbH)
* These authors contributed equally

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Cerebral organoids representerar nya modellsystem att undersöka tidiga mänskliga hjärnans utveckling i vitro. Denna artikel tillhandahåller detaljerade metoden för att effektivt generera homogen dorsala framhjärnan-typ organoids från mänskliga inducerade pluripotenta stamceller inklusive kritiska karakterisering och validering steg.

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Utvecklingsbiologi fråga 131 inducerad pluripotenta stamceller neurobiologi cerebral organoids mänskliga kortikala utveckling kortikala missbildningar sjukdom modellering
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