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JoVE Journal Behavior
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En enkel og billig analyse til måling af Ambulation i musemodeller af Muskelsvindfonden

Article DOI: 10.3791/56772-v • 05:54 min • December 29th, 2017
December 29th, 2017 •
1,2, 1,2,3,4
1Department of Integrative Biology and Physiology, University of California, 2Center for Duchenne Muscular Dystrophy, University of California, 3Department of Neurology, David Geffen School of Medicine, University of California, 4Molecular Biology Institute, University of California

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Denne protokol beskriver en fleksibel, billig system til måling af musen ambulation i en åben mark aktivitet assay. Vi viser, at en 6-minutters ambulation analysen baseret på dette system registrerer et fald i frivillig bevægelse i mdx mus og præcist adskiller forbedring i en muskel-specifikke redning af disse dyr.

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Adfærd spørgsmålet 130 Ambulation dystrofin Duchenne muskeldystrofi motion mdx mus friland skeletmuskulatur utrophin
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