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JoVE Journal Behavior
En enkel og rimelig analysen for å måle Ambulation i musen modeller av muskeldystrofi
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En enkel og rimelig analysen for å måle Ambulation i musen modeller av muskeldystrofi

Article DOI: 10.3791/56772-v • 05:54 min • December 29th, 2017
December 29th, 2017 •
1,2, 1,2,3,4
1Department of Integrative Biology and Physiology, University of California, 2Center for Duchenne Muscular Dystrophy, University of California, 3Department of Neurology, David Geffen School of Medicine, University of California, 4Molecular Biology Institute, University of California

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Denne protokollen beskriver en fleksibel, lavkost system for å måle mus ambulation i åpne-feltet aktivitet analysen. Vi viser at en 6-minutters ambulation analysen basert på dette systemet oppdager en reduksjon i frivillig bevegelse i mdx mus, og nøyaktig skiller forbedring i en muskel-spesifikke redning av disse dyrene.

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Atferd problemet 130 Ambulation dystrophin Duchenne muskeldystrofi trening mdx musen åpne-feltet skjelettlidelser muskel utrophin
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