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Journal / Neuroscience / Kvantitativ måling av γ-Secretase-mediert Amyloid …
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JoVE Journal Neuroscience
Kvantitativ måling av γ-Secretase-mediert Amyloid forløper Protein og hakk Cleavage i celle-baserte Luciferase Reporter analysen plattformer
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Kvantitativ måling av γ-Secretase-mediert Amyloid forløper Protein og hakk Cleavage i celle-baserte Luciferase Reporter analysen plattformer

Article DOI: 10.3791/56795-v • 06:40 min • January 25th, 2018
January 25th, 2018 •
*1, *1, *1, 1, 1, 1, 1
1Laboratory of Molecular Neurobiology, Institute of Cellular and Organismic Biology, Academia Sinica
* These authors contributed equally

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Vi har vellykket generert to substrat-spesifikke γ-secretase analyser. Begge cellebasert analyser som presenteres her er utformet for å kvantifisere γ-secretase enzymatisk aktivitetene via produksjon av firefly luciferase journalister.

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Nevrovitenskap problemet 131 Amyloid forløper protein hakk γ-Secretase Firefly luciferase ErbB2 Alzheimers sykdom Amyloid-β
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