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JoVE Journal
Genetics

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CRISPR/Cas9-mediated 目标集成在体内使用基于同源介导的端接连接策略
 
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CRISPR/Cas9-mediated 目标集成在体内使用基于同源介导的端接连接策略

Article DOI: 10.3791/56844
March 12th, 2018

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Summary March 12th, 2018

Please note that all translations are automatically generated.

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聚簇定期 interspaced 短回文重复/CRISPR 相关蛋白 9 (CRISPR/Cas9) 系统为基因工程提供了一个有前途的工具, 并开辟了转基因目标整合的可能性。我们描述了一种基于同源介导的端接 (HMEJ) 策略, 用于有效的 DNA 靶向集成体内和使用 CRISPR/Cas9 的靶向基因治疗。

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