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Journal / Cancer Research / Rastreio de RNAi todo o genoma para identificar…
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JoVE Journal Cancer Research
Rastreio de RNAi todo o genoma para identificar fatores do hospedeiro que modulam o vírus Oncolíticos terapia
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Rastreio de RNAi todo o genoma para identificar fatores do hospedeiro que modulam o vírus Oncolíticos terapia

Article DOI: 10.3791/56913-v • 08:51 min • April 3rd, 2018
April 3rd, 2018 •
1,2, 1,4, 1, 1, 1,2,3
1Children's Hospital of Eastern Ontario (CHEO) Research Institute, 2Department of Biology, Microbiology and Immunology, University of Ottawa, 3Department of Pediatrics, University of Ottawa, 4Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary

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Aqui descrevemos um protocolo para empregar o rastreio com throughput alto RNAi para descobrir destinos de host que podem ser manipulados para aumentar a terapia de vírus Oncolíticos, especificamente a terapia rhabodvirus e vaccinia vírus, mas pode ser facilmente adaptado para outros Oncolíticos plataformas de vírus ou para descobrir genes de anfitrião que modulam a replicação do vírus em geral.

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Pesquisa sobre o câncer edição 134 Oncolíticos vírus RNAi tela alta produtividade câncer vaccinia Rhabdovírus célula anfitrião genómica funcional
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