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Standardisert måling av nese membran Transepithelial potensielle forskjellen (OD)
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Standardisert måling av nese membran Transepithelial potensielle forskjellen (OD)

Article DOI: 10.3791/57006-v • 09:47 min • September 13th, 2018
September 13th, 2018 •
1, 2, 3, 4, 5, 1, 6,7
1Department of Medicine and the Gregory Fleming James Cystic Fibrosis Center, University of Alabama at Birmingham, 2Department of Pulmonology and Tuberculosis, University Medical Center Utrecht, 3Center for Experimental Medicine, Queens University, Northern Ireland, 4Hadassah Hebrew University Medical Center, Jerusalem, 5Centro Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata, 6Service de Pneumologie et Allergologie Pédiatriques and Center de Ressources et de Compétence de la Mucoviscidose, Hôpital Necker Enfants Malades, 7INSERM U 1151, Institut Necker Enfants Malades

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Her presenterer vi en standardisert protokoll for å måle nasal potensielle forskjellen (OD). Cystisk fibrose transmembrane konduktans regulator (CFTR) og epithelial natrium kanal (ENaC)-funksjonen evalueres etter endringen i spenning over nasal epitel etter superfusion løsninger som endrer ion kanal aktivitet, gir en utfallet tiltaket.

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Medisin problemet 139 Nasal potensiell forskjell cystisk fibrose cystisk fibrose Transmembrane konduktans Regulator CFTR
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