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Journal / Bioengineering / 化学共轭法在戊型肝炎病毒纳米粒子表面功能化中的应用…
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Bioengineering

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JoVE Journal Bioengineering
化学共轭法在戊型肝炎病毒纳米粒子表面功能化中的应用
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化学共轭法在戊型肝炎病毒纳米粒子表面功能化中的应用

Article DOI: 10.3791/57020-v • 09:12 min • May 11th, 2018
May 11th, 2018 •
*1, *1, 1, 1
1Department of Molecular and Cellular Biology, University of California Davis
* These authors contributed equally

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我们已将戊型肝炎病毒的衣壳蛋白作为 theranostic 纳米微粒 (HEVNP) 进行了设计。HEVNP 自组装成一个稳定的 icosahedral 笼在黏膜分娩。在这里, 我们描述了 HEVNPs 的改变的肿瘤靶向性的变异表面暴露残留到半胱氨酸, 共轭合成配体, 具体绑定肿瘤细胞。

Tags

生物工程 135 期 半胱氨酸置换 化学共轭 戊型肝炎 病毒样颗粒 多价蜂胶配体显示 靶向配体
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