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Journal / Bioengineering / Overflade Functionalization af Hepatitis E Virus…
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Bioengineering

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JoVE Journal Bioengineering
Overflade Functionalization af Hepatitis E Virus nanopartikler ved hjælp af kemiske konjugation metoder
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Overflade Functionalization af Hepatitis E Virus nanopartikler ved hjælp af kemiske konjugation metoder

Article DOI: 10.3791/57020-v • 09:12 min • May 11th, 2018
May 11th, 2018 •
*1, *1, 1, 1
1Department of Molecular and Cellular Biology, University of California Davis
* These authors contributed equally

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Vi har manipuleret kapsid proteiner af hepatitis E virus som en theranostic nanopartikel (HEVNP). HEVNP samler selv i en stabil ikosaedriske bur i slimhinden levering. Her beskriver vi ændring af HEVNPs for tumor målretning af muterer overflade-eksponerede rester til cysteines, som konjugat syntetiske ligander, der specifikt binder tumorceller.

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Bioteknologi spørgsmålet 135 cystein udskiftning kemiske konjugering hepatitis E viruslignende partikler multivalent ligand display målretning ligand
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