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Journal / Bioengineering / Ytan funktionalisering av hepatit E Virus…
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Bioengineering

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JoVE Journal Bioengineering
Ytan funktionalisering av hepatit E Virus nanopartiklar med kemiska konjugation metoder
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Ytan funktionalisering av hepatit E Virus nanopartiklar med kemiska konjugation metoder

Article DOI: 10.3791/57020-v • 09:12 min • May 11th, 2018
May 11th, 2018 •
*1, *1, 1, 1
1Department of Molecular and Cellular Biology, University of California Davis
* These authors contributed equally

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Vi har konstruerat det kapsid proteinet av hepatit E-virus som en theranostic nanopartiklar (HEVNP). HEVNP monterar själv in i en stabil ikosaedriska bur i slemhinnor leverans. Här, beskriver vi ändring av HEVNPs för tumör inriktning av muterar yta-exponerade rester till cysteines, som konjugat syntetiska ligander som specifikt binder tumörceller.

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Bioteknik fråga 135 cystein replacement kemiska konjugation hepatit E virusliknande partiklar multivalenta ligand inriktning ligand på display
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