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Journal / Immunology and Infection / Bewertung der zytotoxischen und…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Bewertung der zytotoxischen und immunmodulatorische Wirkung von Substanzen im menschlichen Precision-Cut Lung Slices
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Bewertung der zytotoxischen und immunmodulatorische Wirkung von Substanzen im menschlichen Precision-Cut Lung Slices

Article DOI: 10.3791/57042-v • 12:04 min • May 9th, 2018
May 9th, 2018 •
*1, *1, 1, 1, 1, 2, 2, 3, 4, 4, 5, 1,6, 1
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery, Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology, RWTH Aachen University, 6Institute for Immunology, Hannover Medical School
* These authors contributed equally

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Summary
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Im Hinblick auf die 3R-Prinzips entwickeln sich Atemwege Modelle als Alternativen zum Tierversuch. Vor allem für die Risikobewertung der Atemwege Substanzen ist ein Mangel an entsprechenden Assays. Hier beschreiben wir die Verwendung von menschlichen Lunge präzise geschliffenen Scheiben für die Bewertung von Stoffen in der Luft.

Tags

Immunologie und Infektion Ausgabe 135 menschliche Explant Kultur organotypischen Gewebe Biopsie Lunge Material Ex Vivo Zytotoxizität Immunmodulation konfokale Mikroskopie Chemikalien Precision-Cut Lung slices
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