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Journal / Immunology and Infection / Vurdering af den cytotoksiske og immunmodulerende …
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Vurdering af den cytotoksiske og immunmodulerende virkninger af stoffer i menneskelige præcision-cut lunge skiver
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Vurdering af den cytotoksiske og immunmodulerende virkninger af stoffer i menneskelige præcision-cut lunge skiver

Article DOI: 10.3791/57042-v • 12:04 min • May 9th, 2018
May 9th, 2018 •
*1, *1, 1, 1, 1, 2, 2, 3, 4, 4, 5, 1,6, 1
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery, Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology, RWTH Aachen University, 6Institute for Immunology, Hannover Medical School
* These authors contributed equally

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Summary
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I betragtning af 3R-princippet, respiratorisk modeller som alternativer til dyreforsøg er under udvikling. Især for risikovurdering af respiratorisk stoffer er der en mangel på passende assays. Her, beskriver vi brugen af menneskelige præcision-cut lunge skiver til vurdering af luftbårne stoffer.

Tags

Immunologi og infektion spørgsmålet 135 menneskelige eksplantat kultur organotypic væv biopsi lunge materiale ex vivo cytotoksicitet immunomodulation Konfokal mikroskopi kemikalier præcision-cut lunge skiver
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