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Journal / Immunology and Infection / Beoordeling van de cytotoxische en…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Beoordeling van de cytotoxische en immunomodulerende effecten van stoffen in menselijke precisie-cut Lung plakjes
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Beoordeling van de cytotoxische en immunomodulerende effecten van stoffen in menselijke precisie-cut Lung plakjes

Article DOI: 10.3791/57042-v • 12:04 min • May 9th, 2018
May 9th, 2018 •
*1, *1, 1, 1, 1, 2, 2, 3, 4, 4, 5, 1,6, 1
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery, Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology, RWTH Aachen University, 6Institute for Immunology, Hannover Medical School
* These authors contributed equally

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Met het oog op het 3V-principe, respiratoire modellen als alternatieven voor dierproeven evolueren. Met name voor risico-evaluatie van respiratoire stoffen is er een gebrek aan adequate tests. Hier beschrijven we het gebruik van menselijke precisie-cut Long segmenten voor de beoordeling van airborne stoffen.

Tags

Immunologie en infecties probleem 135 menselijke explant cultuur organotypic weefsel biopsie Long materiaal ex vivo cytotoxiciteit immunomodulatie confocal microscopie chemicaliën precisie-cut Long segmenten
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