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Journal / Immunology and Infection / Vurdering av den cytotoksiske og immunmodulerende …
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Vurdering av den cytotoksiske og immunmodulerende effekter av stoffer i menneskelig presisjonsstyrte kutte lunge skiver
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Vurdering av den cytotoksiske og immunmodulerende effekter av stoffer i menneskelig presisjonsstyrte kutte lunge skiver

Article DOI: 10.3791/57042-v • 12:04 min • May 9th, 2018
May 9th, 2018 •
*1, *1, 1, 1, 1, 2, 2, 3, 4, 4, 5, 1,6, 1
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery, Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology, RWTH Aachen University, 6Institute for Immunology, Hannover Medical School
* These authors contributed equally

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Summary
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I lys av 3Rs prinsipp, er åndedretts modeller som alternativer til dyrestudier utvikling. Spesielt for risikovurdering av respiratoriske stoffer er det mangel på passende analyser. Her beskriver vi bruk av menneskelige presisjonsstyrte kutte lunge skiver for vurdering av luftbåren stoffer.

Tags

Immunologi og infeksjon problemet 135 menneskelige explant kultur organotypic vev biopsi lunge materiale ex vivo cytotoksisitet immunomodulation AC confocal mikroskopi kjemikalier presisjonsstyrte kutte lunge skiver
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