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Journal / Immunology and Infection / Evaluación de la citotóxica y efectos…
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Immunology and Infection

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Evaluación de la citotóxica y efectos inmunomoduladores de sustancias en lonchas de pulmón humano de precisión de corte

Article DOI: 10.3791/57042-v • 12:04 min • May 9th, 2018
May 9th, 2018 •
*1, *1, 1, 1, 1, 2, 2, 3, 4, 4, 5, 1,6, 1
1Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of REBIRTH Cluster of Excellence, 2Institute for Pathology, Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 3Division of Thoracic and Vascular Surgery, Klinikum Region Hannover (KRH), 4Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 5Institute of Pharmacology and Toxicology, RWTH Aachen University, 6Institute for Immunology, Hannover Medical School
* These authors contributed equally

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Teniendo en cuenta el principio 3R, están evolucionando los modelos respiratorios como alternativas a los estudios en animales. Especialmente para la evaluación del riesgo de las sustancias respiratorias, existe una falta de ensayos adecuados. Aquí, describimos el uso de cortes de pulmón humano de precisión de corte para la evaluación de sustancias aerotransportadas.

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Inmunología e infección número 135 explante humana cultura organotypic tejido Biopsia material del pulmón ex vivo citotoxicidad inmunomodulación microscopia confocal productos químicos lonchas de pulmón de precisión de corte
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