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En Flow flowcytometri-baserede analyse til at identificere stoffer, der forstyrrer bindingen af Fluorescently-mærket CXC Chemokine Ligand 12 til CXC Chemokine Receptor 4
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En Flow flowcytometri-baserede analyse til at identificere stoffer, der forstyrrer bindingen af Fluorescently-mærket CXC Chemokine Ligand 12 til CXC Chemokine Receptor 4

Article DOI: 10.3791/57271-v • 06:56 min • March 10th, 2018
March 10th, 2018 •
1, 1, 1, 1, 1
1Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven

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En flow flowcytometri-baserede cellulære bindende assay er beskrevet, som bruges primært som en screeningsværktøj til at identificere stoffer, der hæmmer bindingen af en fluorescently mærket CXC chemokine ligand 12 (CXCL12) til CXC chemokine receptor 4 (CXCR4).

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Molekylærbiologi sag 133 G-protein-koblet receptor CXC chemokine receptor 4 mærket fluorescently chemokine ligand 12 flowcytometri celle-baserede assay receptor binding drug discovery små molekyler Jurkat celler
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