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Journal / Genetics / Promotor captura Hola-C: Perfiles de alta…
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Genetics

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JoVE Journal Genetics
Promotor captura Hola-C
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Promotor captura Hola-C: Perfiles de alta resolución, genoma de interacciones promotor

Article DOI: 10.3791/57320-v • 10:16 min • June 28th, 2018
June 28th, 2018 •
*1, *1,2, 1,3, 1,4, 1,5
1Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, 2IJC Building, Campus ICO-Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, 3Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 4Bioinformatics Group, The Babraham Institute, Babraham Research Campus, 5Department of Biological Science, Florida State University
* These authors contributed equally

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Elementos reguladores del ADN, como potenciadores, controlan la expresión génica físicamente en contacto con promotores de genes de la blanco, a menudo a través de interacciones cromosómicas largo alcance que abarca grandes distancias genómicas. Promotor de captura Hi-C (PCHi-C) identifica interacciones significativas entre promotores y regiones distales, permitiendo la asignación de posibles secuencias reguladoras a sus genes diana.

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Genética número 136 organización del genoma 3D promotores potenciadores interacciones de largo alcance Hi-C cis-elementos reguladores estudio de asociación del genoma completo (GWAS) variantes de la enfermedad no codificante bucles de cromatina CHiCAGO HiCUP
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