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Journal / Genetics / Promotor Capture Hi-C: High-resolution,…
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Genetics

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JoVE Journal Genetics
Promotor Capture Hi-C
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Promotor Capture Hi-C: High-resolution, genoom-brede profilering van promotor interacties

Article DOI: 10.3791/57320-v • 10:16 min • June 28th, 2018
June 28th, 2018 •
*1, *1,2, 1,3, 1,4, 1,5
1Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, 2IJC Building, Campus ICO-Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, 3Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 4Bioinformatics Group, The Babraham Institute, Babraham Research Campus, 5Department of Biological Science, Florida State University
* These authors contributed equally

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DNA regelgevende elementen, zoals versterkers, kwaliteitsbeheersing genexpressie door fysiek contact met target gene initiatiefnemers, vaak door middel van lange-afstands chromosomale interacties verspreid over grote genomic afstanden. Promotor vangen Hi-C (PCHi-C) identificeert belangrijke interacties tussen initiatiefnemers en distale regio's, waardoor de toewijzing van potentiële regulerende sequenties aan hun doelgenen.

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Genetica kwestie 136 3D genoom organisatie initiatiefnemers versterkers lange-afstands interacties Hi-C cis-regelgevende elementen genoom-brede vereniging studie (GWAS) niet-coderende ziekte varianten chromatine lussen CHiCAGO HiCUP
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