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Journal / Genetics / CRISPR 的染色质环结构重组
JoVE Journal
Genetics

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JoVE Journal Genetics
CRISPR 的染色质环结构重组
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CRISPR 的染色质环结构重组

Article DOI: 10.3791/57457-v • 09:20 min • September 14th, 2018
September 14th, 2018 •
*1,2, *1, 1, 3, 4, 5, 1, 1, 1, 5, 3, 1,2,6
1Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, 2Program in Cancer Biology, Stanford University School of Medicine, 3Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, 4Department of Biology, Bridgewater State University, 5System Biosciences, 6Veterans Affairs Healthcare System
* These authors contributed equally

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染色质循环在基因调控中起着重要作用;然而, 没有技术上的进步, 允许选择性和可逆的修饰染色质循环。在这里, 我们描述了一个强大的体系, 染色质循环重组使用 CRISPR-dCas9 (CLOuD9), 证明有选择和可逆调节基因表达在靶点。

Tags

遗传学 问题 139 染色质循环 染色质折叠 基因表达 CRISPR dCas9 基因调节 可逆二聚化 动态染色体重排。
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