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Journal / Genetics / CRISPR-medierad omorganiseringen av kromatin Loop …
JoVE Journal
Genetics

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JoVE Journal Genetics
CRISPR-medierad omorganiseringen av kromatin Loop struktur
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CRISPR-medierad omorganiseringen av kromatin Loop struktur

Article DOI: 10.3791/57457-v • 09:20 min • September 14th, 2018
September 14th, 2018 •
*1,2, *1, 1, 3, 4, 5, 1, 1, 1, 5, 3, 1,2,6
1Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, 2Program in Cancer Biology, Stanford University School of Medicine, 3Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, 4Department of Biology, Bridgewater State University, 5System Biosciences, 6Veterans Affairs Healthcare System
* These authors contributed equally

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Kromatin looping spelar en betydande roll i genreglering; Det har dock inga tekniska framsteg som möjliggör selektiv och reversibel modifiering av kromatin loopar. Här beskriver vi ett kraftfullt system för kromatin loop re-organization använder CRISPR-dCas9 (CLOuD9), visat att selektivt och reversibelt modulera genuttryck på riktade loci.

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Genetik fråga 139 kromatin loopar kromatin vikning gen uttryck CRISPR dCas9 genreglering vändbar dimerization dynamisk kromosomala ombildning.
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