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Adeno-associato Virus-mediate consegna di CRISPR per Gene cardiaco nei topi di Editing
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Adeno-associato Virus-mediate consegna di CRISPR per Gene cardiaco nei topi di Editing

Article DOI: 10.3791/57560-v • 09:00 min • August 2nd, 2018
August 2nd, 2018 •
1, 1, 1, 1
1Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, Ohio State University Wexner Medical Center

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Qui forniamo un protocollo dettagliato per effettuare in vivo gene cardiaco editing nei topi utilizzando Virus ricombinante Adeno-Associated (rAAV)-mediate consegna di CRISPR. Questo protocollo offre una strategia terapeutica di promessa per il trattamento di cardiomiopatia distrofica nella distrofia muscolare di Duchenne e può essere utilizzato per generare specifico knockout in topi postnatali.

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Medicina problema 138 AAV CRISPR Duchenne distrofia muscolare distrofina gene editing mdx ricombinanti virus adeno-associato
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