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转化生长因子β信号诱导内皮-间质转移的分子分析

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

JoVE Journal
Biology

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JoVE Journal Biology

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

转化生长因子β信号诱导内皮-间质转移的分子分析

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11,214 Views

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07:49 min

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August 03, 2018

DOI:

10.3791/57577-v

DOI:

10.3791/57577-v

•

07:49 min

August 03, 2018

•

4 Views

Hiroshi I. Suzuki¹, Masafumi Horie^2,3, Hajime Mihira⁴, Akira Saito²

¹David H. Koch Institute for Integrative Cancer Research,Massachusetts Institute of Technology, ²Department of Respiratory Medicine, Graduate School of Medicine,The University of Tokyo, ³Hastings Center for Pulmonary Research, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine,University of Southern California, ⁴Department of Molecular Pathology, Graduate School of Medicine,The University of Tokyo

Transcript

Summary

本文介绍了一种体外诱导内皮-间质转移 (EndMT) 的方法, 该协议对于研究 EndMT 中涉及的细胞信号通路是有用的。在该实验模型中, EndMT 是由 TGF β在 MS-1 内皮细胞中的治疗引起的。

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