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Journal / Neuroscience / Visualisering af Amyloid β indskud i den…
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Neuroscience

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JoVE Journal Neuroscience
Visualisering af Amyloid β indskud i den menneskelige hjerne med Matrix assisted Laser Desorption/Ionisation Imaging massespektrometri
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Visualisering af Amyloid β indskud i den menneskelige hjerne med Matrix assisted Laser Desorption/Ionisation Imaging massespektrometri

Article DOI: 10.3791/57645-v • 09:31 min • March 7th, 2019
March 7th, 2019 •
*1, *2, 1, 1, 1, 3, 4
1Department of Life and Medical Systems, Doshisha University, 2Bruker Daltonics K.K., 3The Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4Graduate School of Brain Science, Doshisha University
* These authors contributed equally

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Molekylær billeddannelse med matrix assisted laser desorption/Ionisation-baseret tænkelig massespektrometri (MALDI-IMS) tillader den samtidige kortlægning af flere analysander i biologiske prøver. Vi præsenterer her, en protokol til påvisning og visualisering af amyloid β protein på hjernen væv af Alzheimers sygdom og cerebral amyloid angiopathie prøver ved hjælp af MALDI-IMS.

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Neurovidenskab sag 145 MALDI-imaging massespektrometri menneskelige obduktion hjernen amyloid β Alzheimers sygdom senile plaques cerebral amyloid angiopathie
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