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Journal / Cancer Research / 基于免疫荧光显微镜的瞬时和持久双链 dna 损伤 dna…
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Cancer Research

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JoVE Journal Cancer Research
基于免疫荧光显微镜的瞬时和持久双链 dna 损伤 dna 修复过程的表征
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基于免疫荧光显微镜的瞬时和持久双链 dna 损伤 dna 修复过程的表征

Article DOI: 10.3791/57653-v • 08:31 min • June 8th, 2018
June 8th, 2018 •
*1, *1, 2, 1, 1, 1, 1, 1, 1
1Division of Biology, Kansas State University, 2Bristol Medical School, Translational Health Sciences, University of Bristol
* These authors contributed equally

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双链 DNA 断裂的修复是一个动态过程, 不仅需要在断裂时形成修复配合物, 而且要解决病变后的解决方法。在这里, 我们使用免疫荧光显微镜的短暂和长期的双滞留断裂作为一个工具来解剖这个基因组维持机制。

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癌症研究 问题 136 免疫荧光显微镜 DNA 修复 双链断裂 修复动力学 同源重组 非同源端加入 H2AX
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