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JoVE Journal Genetics
Alvéolaire Lavage Exosomen in Lipopolysaccharid-induzierte septischen Lungenschädigung
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Alvéolaire Lavage Exosomen in Lipopolysaccharid-induzierte septischen Lungenschädigung

Article DOI: 10.3791/57737-v • 08:27 min • May 21st, 2018
May 21st, 2018 •
1,2, 1, 1,2
1Department of Veterans Affairs, Atlanta VAMC, 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Emory University

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Mäusen intraperitoneal LPs absondern exosomen in Broncho-alveoläre Lavage (BAL) Flüssigkeit, die mit MiRNAs verpackt sind. Ein Kokulturen-System verwenden, zeigen wir, dass exosomen veröffentlicht in der BAL-Flüssigkeit engen Kreuzung Proteinexpression in bronchialen Epithelzellen stören und Ausdruck von Pro-inflammatorischen Zytokinen, die Lungenschädigung betonen zu erhöhen.

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Ausgabe 135 Exosomen Micro-RNAs MiR-155 Genetik MiR-146a LPS Lunge Sepsis
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