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JoVE Journal
Genetics

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Bronchoalveolar Lavage Exosomes lipopolysakkarid-indusert septisk lungen skade
 

Bronchoalveolar Lavage Exosomes lipopolysakkarid-indusert septisk lungen skade

Article doi: 10.3791/57737
May 21st, 2018

Summary May 21st, 2018

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Mus utsatt for intraperitoneal LPS skiller exosomes i Broncho-alveolar lavage (BAL) væske som er pakket med miRNAs. Bruker en co kultur, viser vi at exosomes utgitt i BAL væske forstyrre uttrykk for tett krysset proteiner i bronkial epitelceller og øke uttrykk for pro-inflammatoriske cytokiner som fremhever lungen skade.

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