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In Vivo Nanovector levering van een hart-specifieke MicroRNA-spons
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In Vivo Nanovector levering van een hart-specifieke MicroRNA-spons

Article DOI: 10.3791/57845-v • 09:53 min • June 15th, 2018
June 15th, 2018 •
1, 2, 2
1Princess Margaret Cancer Centre, University of Toronto, 2Department of Pathology, Department of Cardiology, Johns Hopkins University

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Weefsel-specifieke microRNA remming is een technologie die in het veld microRNA onderontwikkeld is. Hierin beschrijven we een protocol om met succes het remmen van de familie van de miR-181 microRNA in myoblast cellen uit het hart. Nanovector technologie wordt gebruikt voor het leveren van een microRNA spons die significante in vivo cardio-specifieke miR-181 familie remming toont.

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Biologie kwestie 136 MicroRNA miRNA miRNA-spons miRNA inhibitie nanoparticle nanovector miR-181 hart mitochondriale miRNA
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