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JoVE Journal
Developmental Biology

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改良多向分化效力的常规人多能干细胞的化学逆转与幼稚样态
 
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改良多向分化效力的常规人多能干细胞的化学逆转与幼稚样态

Article doi: 10.3791/57921
June 10th, 2018

Summary June 10th, 2018

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我们提出一项协议, 以有效, 散装, 快速化学逆转传统的谱系诱导人类多潜能干细胞 (hPSC) 成一个 epigenomically 稳定幼稚的植入啮鼠动物样多潜能状态。该方法在常规 hPSC 线的多向分化上降低了谱系引种基因的表达和显著改善。

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