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JoVE Journal Neuroscience
Generación y demanda inicio de la actividad Ictal aguda en roedores y tejido humano
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Journal (Neuroscience)
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Generación y demanda inicio de la actividad Ictal aguda en roedores y tejido humano

Article DOI: 10.3791/57952-v • 06:45 min • January 19th, 2019
January 19th, 2019 •
1,2, 1,3, 1,2,3,5,6, 1,2,3,4
1Division of Fundamental Neurobiology, Krembil Research Institute, 2Institute of Medical Science, Faculty of Medicine, University of Toronto, 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4Division of Neurosurgery, Department of Surgery, University of Toronto, 5Division of Neurology, Department of Medicine, University of Toronto, 6Department of Physiology, University of Toronto

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Modelos de convulsión aguda son importantes para el estudio de los mecanismos subyacentes a los eventos epileptiformes. Además, la capacidad para generar eventos epileptiformes en demanda proporciona un método altamente eficiente para estudiar la secuencia exacta de los eventos subyacentes a su iniciación. Aquí, describimos los modelos de crisis cortical aguda 4-aminopiridina en tejido humano y ratón.

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Neurociencia número 143 epileptiformes convulsiones ictal interictal 4-AP optogenetic ChR2 GABA bajo demanda corteza hipocampo
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