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SA-β-Galaktosidasbaserad screening analys för identifiering av Senoterapeutiska läkemedel
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SA-β-Galaktosidasbaserad screening analys för identifiering av Senoterapeutiska läkemedel

Article DOI: 10.3791/58133-v • 07:39 min • June 28th, 2019
June 28th, 2019 •
*1, *1,2,3, 1, 1, 1,2,3, 1,2,3
1Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 2Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 3Institute on the Biology of Aging and Metabolism, University of Minnesota
* These authors contributed equally

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Cellulära åldras är den viktigaste faktorn i utvecklingen av kroniska åldersrelaterade sjukdomar. Identifiering av Therapeutics som riktar sig till senescent celler visar löfte om att förlänga hälsosamt åldrande. Här presenterar vi en ny analys till Screen för identifiering av senotherapeutics baserat på mätning av åldras associerade β-galaktosidas aktivitet i enskilda celler.

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Biologi åldrande Cellsenescens celldöd senescens associerade β-galaktosidas hög genomströmning screening Senolytika Senomorphics Senotherapeutics
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