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Cancer Research

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JoVE Journal Cancer Research
c-fos 和 dusp1 在癌基因依赖性中的作用评价方法
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c-fos 和 dusp1 在癌基因依赖性中的作用评价方法

Article DOI: 10.3791/58194-v • 10:09 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1
1Cancer Blood Disease Institute, Divisions of Experimental Hematology and Cancer Pathology, Cincinnati Children's Hospital Medical Center

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在这里, 我们描述了 c-fos 和 dusp1 作为白血病药物靶标的遗传和化学验证协议, 在体外和体内使用遗传和人性化的小鼠模型。该方法可应用于遗传验证和治疗发展的任何目标。

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癌症研究 第143期 酪氨酸激酶抑制剂 慢性粒细胞白血病 最小残留疾病 酪氨酸激酶 白血病干细胞 癌基因成瘾 治疗阻力 骨髓移植 小鼠模型
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