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Journal / Bioengineering / Reprimere la trascrizione genica reindirizzando…
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JoVE Journal Bioengineering
Reprimere la trascrizione genica reindirizzando macchinario cellulare con modificatori epigenetici chimici
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Reprimere la trascrizione genica reindirizzando macchinario cellulare con modificatori epigenetici chimici

Article DOI: 10.3791/58222-v • 10:28 min • September 20th, 2018
September 20th, 2018 •
1, 2, 3, 3, 4
1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina

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Regolamento dell'ambiente della cromatina è un processo essenziale necessario per l'espressione genica corretto. Qui, descriviamo un metodo per il controllo dell'espressione genica attraverso il reclutamento di modificante la cromatina macchinari in modo gene-specifico e reversibile.

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Bioingegneria problema 139 biologia chimica molecole bifunzionali chimica indotta prossimità regolazione della cromatina repressione genica istone deacetilasi epigenetica chimici modificatori epigenetici CEMs
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