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Journal / Immunology and Infection / Humaniseret SCID-NOD-IL2rγnull (hu-NSG) mus Model …
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Immunology and Infection

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JoVE Journal Immunology and Infection
Humaniseret SCID-NOD-IL2rγnull (hu-NSG) mus Model for HIV replikation og Latency undersøgelser
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Humaniseret SCID-NOD-IL2rγnull (hu-NSG) mus Model for HIV replikation og Latency undersøgelser

Article DOI: 10.3791/58255-v • 07:10 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1,2, 1, 1
1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Irell and Manela Graduate School of Biological Sciences, Beckman Research Institute of City of Hope

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Denne protokol indeholder en metode til at etablere humaniseret mus (hu-NSG) via intrahepatisk injektion af menneskelige hæmatopoietisk stamceller i stråling-aircondition neonatal NSG mus. Hu-NSG musen er modtagelige for HIV-infektion og kombinatorisk antiretroviral behandling (vogn) og tjener som en passende patofysiologiske model for HIV replikation og latency undersøgelser.

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Immunologi og infektion spørgsmålet 143 Neonatal NSG mus humaniseret mus HSCs HIV indkøbskurv ventetid
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