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Journal / Immunology and Infection / (Hu-NSG) souris humanisée NOD/SCID/IL2rγnull…
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Immunology and Infection

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JoVE Journal Immunology and Infection
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(Hu-NSG) souris humanisée NOD/SCID/IL2rγnull modèle d’études de latence et de réplication du VIH

Article DOI: 10.3791/58255-v • 07:10 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1,2, 1, 1
1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Irell and Manela Graduate School of Biological Sciences, Beckman Research Institute of City of Hope

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Ce protocole fournit une méthode pour établir des souris humanisées (hu-NSG) via intrahépatique injection de cellules souches hématopoïétiques humaines à des souris NSG néonatales conditionné par rayonnement. La souris de l’hu-NSG est sensible à l’infection par le VIH et combinatoire antirétrovirales (cART) et sert de modèle physiopathologique adapté pour les enquêtes de réplication et latence du VIH.

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Immunologie et Infection numéro 143 souris néonatales NSG humanisé souris csh VIH panier latence
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