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Journal / Immunology and Infection / (Hu-NSG) ratón humanizado del NOD/SCID/IL2rγnull…
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Immunology and Infection

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JoVE Journal Immunology and Infection
(Hu-NSG) ratón humanizado del NOD/SCID/IL2rγnull modelo para estudios de latencia y replicación del VIH
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(Hu-NSG) ratón humanizado del NOD/SCID/IL2rγnull modelo para estudios de latencia y replicación del VIH

Article DOI: 10.3791/58255-v • 07:10 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1,2, 1, 1
1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Irell and Manela Graduate School of Biological Sciences, Beckman Research Institute of City of Hope

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Este protocolo proporciona un método para crear ratones humanizados (hu-NSG) vía intrahepática inyección de células madre hematopoyéticas humanas en ratones NSG neonatales radiación-condicionada. El ratón hu-NSG es susceptible a la infección por VIH y la terapia combinatoria antirretroviral (carro) y sirve como un modelo fisiopatológico adecuado para investigaciones de replicación y latencia del VIH.

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Inmunología e infección número 143 ratón Neonatal NSG humanizado ratones HSCs VIH carro latencia
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