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JoVE Journal Immunology and Infection
Antigen liposomer for generering av sykdom-spesifikke antistoffer
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Antigen liposomer for generering av sykdom-spesifikke antistoffer

Article DOI: 10.3791/58285-v • 10:31 min • October 25th, 2018
October 25th, 2018 •
*1, *2,3, *3,4, 5, 6, 3,4, 5,7
1Janssen R&D, 2Department of Microbiology and Immunology, University of North Carolina, 3UNC Food Allergy Initiative, University of North Carolina, 4Department of Pediatrics, University of North Carolina, 5Department of Chemistry, University of Alberta, 6Department of Molecular Medicine, Scripps Research Institute, 7Department of Medical Microbiology and Immunology, University of Alberta
* These authors contributed equally

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Beskrevet er utarbeidelsen av antigen liposomal nanopartikler og deres bruk i stimulerende B-celle aktivering i vitro og vivo. Konsekvent og robust antistoff svar førte til utviklingen av en ny peanøttallergi modell. Protokollen for å generere antigen liposomer kan utvides til forskjellige antigener og immunisering modeller.

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Immunologi og infeksjon problemet 140 nanopartikler liposomer anafylaksi Peanut allergi kalsium Flux Flow cytometri spesifikke Antigen Ara h 2 matallergi IgE
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