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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

Article DOI: 10.3791/58332-v • 10:16 min • October 12th, 2018
October 12th, 2018 •
*1, *1, 1, 2
1Biomedical Engineering, Translational Tissue Engineering Center, Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, 2Biomedical Engineering, Translational Tissue Engineering Center, Institute for Nanobiotechnology, Ophthalmology, Oncology, Neurosurgery, Materials Science and Engineering, Chemical and Biomolecular Engineering, and the Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine
* These authors contributed equally

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Summary
Automatic Translation

Here, we present a protocol to quickly and reproducibly generate biologically inspired, biodegradable articifical antigen presenting cells (aAPC) with tunable size, shape, and surface protein presentation for T cell expansion ex vivo or in vivo.

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Anisotropic Polymeric Artificial Antigen Presenting Cells CD8+ T Cell Activation Amino-engineering Particle Physical Properties Biomaterial Immune Cell Interactions Activation Size And Shape Control Biomimetic Particles Cancer Therapy In Vivo Cell Mediated Immune Responses Infectious Disease Type One Diabetes Micro-particle Synthesis Poly(lactic-co-glycolic Acid) PLGA Dichloromethane Polyvinyl Alcohol PVA Solution
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