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Journal / Cancer Research / Overflade-forstærket resonans Raman spredning…
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Cancer Research

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JoVE Journal Cancer Research
Overflade-forstærket resonans Raman spredning Nanoprobe Ratiometry til påvisning af mikroskopiske æggestokkræft via folat Receptor målretning
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Overflade-forstærket resonans Raman spredning Nanoprobe Ratiometry til påvisning af mikroskopiske æggestokkræft via folat Receptor målretning

Article DOI: 10.3791/58389-v • 07:54 min • March 25th, 2019
March 25th, 2019 •
1, 1, 1, 1,2, 1, 1,3,4,5,6,7
1Department of Radiology, Memorial Sloan Kettering Cancer Center, 2Department of Chemistry, The Graduate Center of the City University of New York, 3Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, 4Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, 5Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 6Department of Radiology, Weill Cornell Medical College of Cornell University, 7Dana-Farber Cancer Institute and Harvard Medical Center

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Kræft i æggestokkene danner metastaser i hele bughulen. Her præsenterer vi en protokol til at foretage og brug folat-receptor målrettet overflade-forstærket resonans Raman spredning nanoprobes, der afslører disse læsioner med høj specificitet via ratiometric imaging. Nanoprobes er blevet administreret intraperitoneal til levende mus, og de afledte billeder korrelere godt med histologi.

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Kræftforskning sag 145 Raman SERS nanopartikel molekylær billeddannelse kræft i æggestokkene folat receptor ratiometry
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