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JoVE Journal Cancer Research
Overvåking Hippo signalering Pathway aktivitet ved hjelp av en Luciferase-baserte store Tumor Suppressor (LATS) Biosensor
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Overvåking Hippo signalering Pathway aktivitet ved hjelp av en Luciferase-baserte store Tumor Suppressor (LATS) Biosensor

Article DOI: 10.3791/58416-v • 07:16 min • September 13th, 2018
September 13th, 2018 •
*1, *1, 1, 1, 1
1Department of Pathology and Molecular Medicine, Queen's University
* These authors contributed equally

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Her presenterer vi en luciferase-baserte biosensor for å kvantifisere kinase aktiviteten til store tumor suppressor (LATS)-en sentral kinase i Hippo signalveien. Denne biosensor har forskjellige programmer i grunnleggende og translasjonsforskning forskning å undersøke Hippo veien regulatorer i vitro og vivo.

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Kreftforskning problemet 139 LATS LATS biosensor Hippo veien delt luciferase analysen cellekultur narkotikarelaterte screening kinase
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