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Cancer Research

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JoVE Journal Cancer Research
Syngeneic musen B-celle lymfom Model for præ-klinisk evaluering af CD19 bil T celler
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Syngeneic musen B-celle lymfom Model for præ-klinisk evaluering af CD19 bil T celler

Article DOI: 10.3791/58492-v • 12:16 min • October 16th, 2018
October 16th, 2018 •
1, 1, 1, 1,2, 1
1Manchester Cancer Research Centre Building, Department Cancer Sciences, University of Manchester, 2Celyad

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Vi præsenterer her, en protokol for produktion og præ-klinisk afprøvning af murine CD19 bil T celler af retroviral transduktion og udnyttelse som en terapi mod etablerede syngeneic A20 B-celle lymfom i BALB/c mus med eller uden lymphodepleting forudgående konditionering.

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Kræftforskning spørgsmål 140 bil T celler lastbiler adoptiv T-celle terapi syngeneic med musen model A20 immunterapi IL-12 forudgående konditionering CD19 lymfom
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