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JoVE Journal Chemistry
Um novo método simples para a medição de Lipofilicidade (logP) usando 19espectroscopia RMN de F
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Um novo método simples para a medição de Lipofilicidade (logP) usando 19espectroscopia RMN de F

Article DOI: 10.3791/58567-v • 09:32 min • January 30th, 2019
January 30th, 2019 •
1, 1, 1, 1, 2, 1
1Chemistry, University of Southampton, 2Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca

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Um romance e uma variação simples do método agitar-balão foi desenvolvido para a medição exata Lipofilicidade de compostos fluorados por espectroscopia de RMN de F 19.

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Química questão 143 Lipofilicidade organofluorados 19F NMR fluoração alkanols de gases fluorados hidratos de carbono
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