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Répression de la croissance de cellules de myélome Multiple In Vivo par Nanotube de carbone monoparoi (NCM)-livré MALAT1 oligonucléotides antisens
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Répression de la croissance de cellules de myélome Multiple In Vivo par Nanotube de carbone monoparoi (NCM)-livré MALAT1 oligonucléotides antisens

Article DOI: 10.3791/58598-v • 07:24 min • December 13th, 2018
December 13th, 2018 •
*1,2, *1, 1
1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
* These authors contributed equally

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Ce manuscrit décrit la synthèse d’un nanotube de carbone monoparoi (NCM)-conjugué MALAT1 gapmer antisens ADN d’oligonucléotide (SWCNT-anti-MALAT1), qui montre la remise fiable du NCM et le puissant effet thérapeutique de anti-MALAT1 in vitro et in vivo. Méthodes utilisées pour la synthèse, de modification, de conjugaison, et injection de SWCNT-anti-MALAT1 sont décrites.

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Recherche sur le cancer numéro 142 monoparoi carbone nanotube NCM myélome multiple MALAT1 longtemps non codantes RNA lncRNA
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