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Undertrykkelse av myelom cellevekst i Vivo av enkelt-vegg Carbon nanorør (SWCNT)-levert MALAT1 Antisense Oligos
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Undertrykkelse av myelom cellevekst i Vivo av enkelt-vegg Carbon nanorør (SWCNT)-levert MALAT1 Antisense Oligos

Article DOI: 10.3791/58598-v • 07:24 min • December 13th, 2018
December 13th, 2018 •
*1,2, *1, 1
1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
* These authors contributed equally

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Dette manuskriptet beskriver syntesen av en enkelt-vegg carbon nanorør (SWCNT)-konjugert MALAT1 antisense gapmer DNA oligonucleotide (SWCNT-anti-MALAT1), som viser pålitelig levering av SWCNT og den potente terapeutiske effekten av anti-MALAT1 i vitro og in vivo. Metoder brukt for syntese, modifisering, bøyning og injeksjon av SWCNT-anti-MALAT1 er beskrevet.

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Kreftforskning problemet 142 enkelt-vegg carbon nanorør SWCNT multippel myelom MALAT1 lenge ikke-koding RNA lncRNA
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