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Journal / Biochemistry / Een Rat Methyl-Seq Platform om epigenetische…
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Biochemistry

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JoVE Journal Biochemistry
Een Rat Methyl-Seq Platform om epigenetische veranderingen Associated with Stress Exposure te identificeren
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Een Rat Methyl-Seq Platform om epigenetische veranderingen Associated with Stress Exposure te identificeren

Article DOI: 10.3791/58617-v • 09:06 min • October 24th, 2018
October 24th, 2018 •
1, 1, 1, 1, 1, 1,3, 1,2, 1
1Departments of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 2Department of Medicine, Johns Hopkins School of Medicine, 3Department of Mental Health, Johns Hopkins School of Public Health

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We beschrijven hier, het protocol en de uitvoering van Methyl-Seq, een epigenomic-platform, met behulp van een rat-model om epigenetische veranderingen die zijn gekoppeld aan chronische stress blootstelling te identificeren. Resultaten tonen aan dat de rat Methyl-Seq platform is voor het opsporen van methylation van verschillen die uit stress blootstelling bij ratten voortvloeien van.

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Biochemie kwestie 140 epigenetica methylation van DNA rat Methyl-Seq stress neuroendocrinologie
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