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Journal / Immunology and Infection / Automatisert atferdsdata analyse av store C.…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Automatisert atferdsdata analyse av store C. elegans bestander bruke et bredt felt-of-view sporing Platform
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Automatisert atferdsdata analyse av store C. elegans bestander bruke et bredt felt-of-view sporing Platform

Article DOI: 10.3791/58643-v • 07:20 min • November 28th, 2018
November 28th, 2018 •
1, 1, 1, 2, 1, 1, 1
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen

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Vi beskriver protokoller for bruker bredt felt-of-view Rundormer sporing plattformen (WF-NTP), som gir høy gjennomstrømming fenotypiske karakteristikk av store bestander av Caenorhabditis elegans. Disse protokollene kan brukes til å beskrive subtile atferdsendringer i mutant stammer eller som svar på farmakologisk behandling i en skalerbar måte.

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Immunologi og infeksjon problemet 141: Drug discovery fenotype-basert screening høy gjennomstrømming screening C. elegans amyloid formasjon Alzheimers sykdom neurodegeneration Rundormer biblioteket store befolkningen analyse
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