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Paramyxoviruses para imunomodulação Tumor-alvo
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Paramyxoviruses para imunomodulação Tumor-alvo: Design e avaliação Ex Vivo

Article DOI: 10.3791/58651-v • 12:42 min • January 7th, 2019
January 7th, 2019 •
1,2, 1,3
1Department of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 2Faculty of Biosciences, Heidelberg University, 3Department of Medical Oncology, NCT and Heidelberg University Hospital

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Este protocolo descreve um fluxo de trabalho detalhado para a geração e ex vivo caracterização de vírus Oncolíticos para expressão de imunomoduladores, usando vírus de sarampo codificação participantes de célula T bispecific como exemplo. Aplicação e adaptação para outras plataformas de vetor e transgenes irão acelerar o desenvolvimento do romance immunovirotherapeutics de tradução clínica.

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Cancer Research edição 143 virotherapy Oncolíticos imunoterapia vetores virais vírus do sarampo paramixovírus bispecific células T engager
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