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Nanopartículas de óxido de ferro revestido de Polyethyleneimine como um veículo para a entrega de RNA de interferência pequeno para macrófagos In Vitro e In Vivo

Article DOI: 10.3791/58660-v • 09:36 min • February 5th, 2019
February 5th, 2019 •
*1, *2, 1, 1, 2, 2, 1
1Key Laboratory of Ministry of Education for Developmental Genes & Human Diseases, Institute of Life Sciences and School of Medicine, Southeast University, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials & Devices, School of Biological Science & Medical Engineering, Southeast University
* These authors contributed equally

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Nós descrevemos um método de usar polyethyleneimine (PEI)-revestido de nanopartículas de óxido de ferro superparamagnético para macrófagos transfecting com siRNA. Essas nanopartículas podem eficientemente entregar siRNA expressão macrófagos gene-alvo em vitro e in vivo e silêncio.

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Medicina edição 144 macrófago transfecção nanopartículas entrega de siRNA polyethyleneimine veículo silenciamento de genes
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