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JoVE Journal Biochemistry
Met behulp van hoog gehalte Imaging om te kwantificeren Target Engagement in Adherente cellen
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Met behulp van hoog gehalte Imaging om te kwantificeren Target Engagement in Adherente cellen

Article DOI: 10.3791/58670-v • 07:23 min • November 29th, 2018
November 29th, 2018 •
1,2, 1,2, 1,3
1Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institutet, Solna, 2Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, 3Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm

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Metingen van de drug target betrokkenheid staan centraal in effectieve Geneesmiddelenontwikkeling en chemische sonde validatie. Hier, detail we een protocol voor het meten van de drug-target engagement met behulp van hoge inhoud imaging in een microplate-compatibele adaptie van de cellulaire thermische shift test (CETSA).

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Biochemie kwestie 141 cellulaire thermische shift assay (CETSA) beeldvorming doel betrokkenheid p38α high-throughput screening eencellige resolutie
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