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Journal / Cancer Research / En tredimensionel Thymisk kultur system til at…
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Cancer Research

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JoVE Journal Cancer Research
En tredimensionel Thymisk kultur system til at generere murine induceret pluripotente stamcelle-afledte tumor antigen-specifikke Thymisk emigranter
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En tredimensionel Thymisk kultur system til at generere murine induceret pluripotente stamcelle-afledte tumor antigen-specifikke Thymisk emigranter

Article DOI: 10.3791/58672-v • 10:44 min • August 9th, 2019
August 9th, 2019 •
*1,2, *1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1, 3, 1,2
1Surgery Branch, National Cancer Institute, NIH, 2Center for Cell-Based Therapy, National Cancer Institute, NIH, 3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH
* These authors contributed equally

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Denne artikel beskriver en ny metode til at generere tumor antigen-specifikke induceret pluripotente stamcelle-afledte thymisk emigranter (iTE) af en tredimensionel (3D) thymisk kultur system. iTE er en homogen delmængde af T-celler tæt relateret til naive T-celler med kapacitet til spredning, hukommelse dannelse, og tumor suppression.

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Kræftforskning stamcelle induceret pluripotente stamcelle immunologi adoptiv celle overførsel T Celledifferentiering tumor antigen specificitet 3D-kultur føtal thymisk organ kultur
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