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Journal / Immunology and Infection / Induktion af mus lungeskade ved Endotracheal…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Induktion af mus lungeskade ved Endotracheal injektion af bleomycin
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Induktion af mus lungeskade ved Endotracheal injektion af bleomycin

Article DOI: 10.3791/58922-v • 06:52 min • April 30th, 2019
April 30th, 2019 •
*1, *2, 2, 2, 2, 3, 3, 1, 2, 2
1Servizio di Allevamento e Sperimentazione Animale, Polo ScientificoTecnologico, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)-Istituto Nazionale Ricovero e Cura Anziani (INRCA), 2Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, 3UOS Centro di Terapia Cellulare "G. Lanzani", Azienda Socio Sanitaria Territoriale (ASST) Papa Giovanni XXIII
* These authors contributed equally

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Her præsenterer vi en effektiv metode til at undersøge den anti fibrotiske aktivitet af intravenøst inanvendte humane mesenchymale stromale celler opnået fra hele navlestrengen efter induktion af lungeskade ved en endotracheal tubus injektion af bleomycin i C57BL /6 mus. Denne protokol kan let udvides til den prækliniske testning af andre terapeutiske midler.

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Immunologi og infektion bleomycin endotracheal tubus injektion lungeskade humane navlestrengen mesenchymal stromale celler (hUC-MSC) hale vene infusion C57BL/6 mus
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